Aminoglutethimide: a 'side-effect' turned to therapeutic advantage
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Aminoglutethimide: a "side-effect" turned to therapeutic advantage.
Aminoglutethimide was introduced as an anticonvulsant drug in the U.S.A. in 1960. The occurrence of a number of side-effects, including several endocrine effects such as goitrogenesis, sexual precocity and virilization, led to its withdrawal. Further investigation indicated that the drug inhibited adrenal biosynthesis, particularly of aldosterone, cortisol and androgens, probably by interfering...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1970
ISSN: 0032-5473
DOI: 10.1136/pgmj.46.537.409